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";s:4:"text";s:2509:"Sci. Activated JNK and p38 translocate to the nucleus where they activate multiple transcription factors, via MSK1/2 in the case of p38, including AP-1, ATF2, CREB, ATF1, and NF-kappa B. Pathway analysis showed that Angptl7 promoted the phosphorylation of both p65 and p38, but only the P38 mitogen-activated protein kinase (MAPK) signaling pathway mediated Angptl7-associated inflammatory functions. TTP promotes mRNA deadenylation [4, 9], whereas p38 MAPK inhibits it and TTP is a substrate of the kinase downstream of p38 MAPK, MAPK‐activated protein kinase 2 (MK2) . ... to promote inflammation via the stabilization and translation of proinflammatory gene mRNA. p38 MAPKs are also known as stress-activated serine/threonine-specific kinases (SAPKs). Rep. 6 , … The p38 MAPK pathway plays a crucial role in the release of pro-inflammatory cytokines such as IL-6 and has been implicated in acute lung injury and myocardial dysfunction. Keywords: dendritic cell-restricted progenitors, CDPs, obesity, asthma, Adam17, p38 MAPK pathway. Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells. MAPK14 encodes p38α mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family. Thus, the search for more inflammation-specific p38 MAPK inhibitors is underway, focusing on the therapeutic potential of different isoforms of p38 MAPK (p38α and p38γ appear to be the dominant isoforms expressed and activated in synovial tissue from RA patients) and regulatory elements upstream of p38 activation [54, 85–87]. Circumstantial evidence suggests that the p38 MAPK pathway regulates mRNA stability by inactivating TTP. The overwhelming inflammatory response in COVID-19 infection may be caused by disproportionately upregulated p38 activity, explained by two mechanisms. MAPK Signaling Pathway: Mitogen Stimulation Pathway ... respectively. The suppressed p38 MAPK signaling pathway was associated with less caspase-1+PI+ pyroptotic cell population as analyzed by flow cytometry. Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. In addition, Angptl7 antagonized the anti-inflammatory effects of TGF-β1 and dexamethasone. Thus, the blockage of p38 MAPK signaling pathway has the potential to suppress excessive lung inflammation by inhibiting inflammatory macrophage pyroptosis-biased cell death. 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