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In 1974, ribosomal protein S6 was discovered and has aroused much interest due to the temporal correlation of ribosomal protein S6 with protein synthesis. TEXT. Here, we report that ribosomal S6 protein kinase 4 (RSK4) plays a pivotal role in promoting CSC properties and radioresistance in ESCC. We have now identified the first small-molecule, RSK-specific inhibitor, which we isolated from the tropical plant Forsteronia refracta .

There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with K i /IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively.

Description. The PI3K/mTOR signallin …

SL0101 shows remarkable specificity for RSK. RSK4 was found to be a direct downstream transcriptional target of ΔNp63α, the main p63 isoform, which is frequently amplified in ESCC. S6K2 p70 S6 KINASE, BETA p70(S6K)-BETA p70-BETA HGNC Approved Gene Symbol: RPS6KB2. In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction.There are two subfamilies of rsk, p90 rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70 rsk, also known as S6-H1 Kinase or simply S6 Kinase.There are three variants of p90 rsk in humans, rsk 1-3. p90 ribosomal S6 kinase (RSK) is an important downstream effector of mitogen-activated protein kinase, but its biological functions are not well understood. RIBOSOMAL PROTEIN S6 KINASE, 70-KD, 2; RPS6KB2 Alternative titles; symbols. SL0101 shows remarkable specificity for RSK. S6K1 (p70 ribosomal S6 kinase 1) is activated by insulin and growth factors via the PI3K (phosphoinositide 3-kinase) and mTOR (mammalian target of rapamycin) signalling pathways. TEXT. There are three variants of p90rsk in humans, rsk 1-3. p90 ribosomal S6 kinase (RSK) is an important downstream effector of mitogen-activated protein kinase, but its biological functions are not well understood. PF-4708671 induces autophagy. RSK4 was highly expressed in ESCC CSCs and associated with radioresistance and poor survival in patients with ESCC. We have named this novel inhibitor SL0101. We have now identified the first small-molecule, RSK-specific inhibitor, which we isolated from the tropical plant Forsteronia refracta . S6K2 p70 S6 KINASE, BETA p70(S6K)-BETA p70-BETA HGNC Approved Gene Symbol: RPS6KB2. The p90 ribosomal S6 kinase (RSK) family is a group of highly conserved Ser/Thr kinases that promote cell proliferation, growth, motility and survival.

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